Scientific Program 11th Edition

Download the page_white_acrobat SYMPOSIUM PROGRAM

THURSDAY, 29th May 2014

THURSDAY, 29th May 2014
7:45 – 8:30 REGISTRATION
8:30 – 9:00 WELCOMING
9:00 – 10:00 OPENING LECTURES
Frontiers of cardiac regeneration. Is there a role in advanced heart disease?

Chairs: John Martin (London, UK)
Andreas Zeiher (Frankfurt, Germany)

9:00 – 9:20 The Biological point of view.
Stefanie Dimmeler (Frankfurt, Germany)
9:20 – 9:40 The Clinical point of view.
Bernard Gersh (Rochester, USA)
9:40 – 10:00 The contribution of animal models of cardiac disease
Steven Chamuleau (Utrecht, The Netherlands)
10.00 – 10.20 COFFEE BREAK
10:20 – 12:45 WHAT’S NEW IN STEM CELL THERAPY FOR CARDIACREPAIR?

Chairs:Kai C. Wollert (Frankfurt, Germany)
Angel Raya (Barcelona, Spain)

Panel Discussants: Felipe Atienza (Madrid, Spain)
Dominique Charron (Paris, France)
Stefanie Dimmeler (Frankfurt, Germany)
Roberto Fdez-Viña (Buenos Aires, Argentina)

10:20 – 10:40 Types of Cells – Only the lonely
Bernardo Nadal-Ginard (Liverpook, UK)
10:40 – 11:00 Types of Cells – Not only the lonely
Joshua Hare (Miami, USA)
11:00 – 11:20 Mechanisms of action. Still exogenous cell replacement or again paracrine modulation?
Atta Behfar (Rochester, USA)
11:20 – 11:40 Cyclin A2 induces cardiac regeneration after myocardial infarction through cytokinesis of adult cardiomyocytes.
Hina W. Chaudry (New York, USA)
11:40 – 12:00 Electrical coupling for real functional regeneration. The necessary contribution of electrophysiology.
Angel Arenal (Madrid, Spain)
12:00 – 12:20 Delivery and tracking. Finding a well-hidden needle in the haystack
Javier Bermejo (Madrid, Spain)
12:20 – 12:45 Panel Discussion
12:45 – 13:30 LUNCH AND POSTER EXHIBITION

Chairs and jury: Philippe Menasche (Paris, France)
Felipe Prosper (Pamplona, Spain)

In this “Poster Exhibition” research teams involved in the topic of the Symposium will have the opportunity of presenting selected parts of their work to the audience.

The Poster Review Committee will select which the best posters of the session are. At the end of the session, the verdict will be communicated. The winners of the Posters Awards will have to present their work (oral pres-entation) the following day in the morning, in the session named “Best Poster Presentation”, when they will receive their prize.

For more information regarding Poster Exhibition and Poster Awards, please contact us via e-mail at
posters@cardiovascularcelltherapy.com

13:30 – 16:00 LATE BREAKING HEART TISSUE ENGINEERING

Chairs: Stefan Janssens (Belgium)
Pedro L. Sánchez (Salamanca, Spain)

Panel Discussants: Angel Arenal (Madrid, Spain)
Javier Bermejo (Madrid, Spain)
Brooke Helfer (San Diego, USA)
Bernardo Nadal-Ginard (Liverpool, UK)

13:30 – 13:50 Replacement of extracellular architecture by artificial tissues
Juan Carlos Chachques (Paris, France)
13:50 – 14:10 Role of cadaveric scaffolds in advanced cardiac disease
Doris Taylor (Houston, USA)
14:10 – 14:30 Can intramyocardial delivery repair extracellular structure?
Jerome Roncalli (Toulouse, France)
14:30 – 14:50 Enhacing retention and efficacy of cardiosphere-derived cells administered after myocar dial infarction using a hyaluronan-gelatin hydrogel
Rachel Ruckdeschel Smith (Los Angeles, USA)
14:50 – 15:10 Role of electrophysiology in the production of bioartificial myocardium
Andreu M. Climent (Madrid, Spain)
15:10 – 15:30 The long and winding road to building a biological valve
Amir Lerman (Rochester, USA)
15:30 – 16:00 Panel Discussion
16:00 – 18:00 DISCOVERIES AND INVENTIONS

Chairs: Juan Carlos Izpisúa (La Jolla, USA)
Didier Locca (Lugano, Switzerland)

Panel Discussants: Atta Behfar (Rochester, USA)
Amir Lerman (Rochester, USA)
Stefanie Dimmeler (Frankfurt, Germany)
Andreas Zeiher (Frankfurt, Germany)
James T. Willerson (Houston, USA)

16:00 – 16:20 Genetic manipulation of cells to enhance cardiac repair
Roger Hajjar (New York, USA)
16:20 – 16:40 Perfusable microvessel networks and perfusion platforms for engineered tissues
Milica Radisic (Toronto, Canada)
16:40 – 17:00 MicroRNAs in cardiac development and regeneration
Enzo R. Porrello (Queensland, Australia)
17:00 – 17:20 Exosomes and cardiac repair after myocardial infarction.
Douglas W. Losordo (Chicago, USA)
17:20 – 17:40 MYDGF protein therapy improves infarct healing
Kai C. Wollert (Hannover, Germany)
17:40 – 18:00 Panel Discussion
18:00 – 20:00 EDUCATIONAL WORKSHOPS
1. Clinical research in stem cell therapy. Advances, barriers and pitfalls.
2. Application of tissue engineering discoveries. Opportunities and impediments
3. Cell production and delivery.
EDUCATIONAL WORKSHOP 1 (ROOM 1)
Clinical research in stem cell therapy. Advances, barriers and pitfalls
CoordinatorsBernard Gersh
Ricardo Sanz Ruiz
Panel discussants Javier Bermejo
Douglas W. Losordo
Emerson Perin
Sol Ruiz
Andreas Zeiher
18.00 – 18.10 The problem endpoints. Only mortality? Role of the quality
of life and functional status
Bernard Gersh (Rochester, USA)
18.10 – 18.30 Pannel Discussion
18.30 – 18.40 The problem of myocardial damage measurement. Reality
and imagination of imaging techniques
Raquel Yotti (Madrid, Spain)
18.40– 19.00 Pannel Discussion
19.00 – 19.10 The problem of recruitment. Berriers and solutions from the
US perspective. Applicable in Europe?
Thimothy Henry (Los Angeles, USA)
19.10 – 19.30 Pannel Discussion
19.30– 19.40 Role of GCSF after AMI. STEM-AMI
Giulio Pompilio (Milan, Italy)
19.40– 20.00 Pannel Discussion
EDUCATIONAL WORKSHOP 2 (ROOM 2)
Applicability of tissue engineering discoveries. Opportunities and impediments
CoordinatorsDoris A. Taylor
Pedro L. Sanchez
Panel Discussants Angel Arenal
Joseph Consiglio
Amir Lerman
18.00 – 18.10 Sequence and integration of experimental models
Andreu M. Climent (Madrid, Spain)
18.10 – 18.30 Pannel Discussion
18.30 – 18.40 The problem of cell-to-cell and cell-to-tissue interaction. Role of
tissue engineering
Felipe Atienza (Madrid, Spain)
18.40 – 19.00 Pannel Discussion
19.00 – 19.10 Artificial vs bioartificial matrixes: homo or Xeno Scaffolds?
Doris A. Taylor (Texas, USA)
19.10 – 19.30 Pannel Discussion
19.30 – 19.40 Novel tracking technologies: fluorine-19 magnetic resonance
Imagining and its impact on stem cells
Brooke Helfer (San Diego, USA)
19.40 – 20.00 Pannel Discussion
EDUCATIONAL WORKSHOP 3 (ROOM 3)
Cell production for clinical trials
Coordinators  Mª Eugenia Fernández Santos
Philippe Menasché
Pannel Discussants Stefanie Dimmeler
Bernardo Nadal
Felipe Prósper
Rachel Ruckdeschel Smith
18.00 – 18.10 Cardiopoietic mesenchymal stem cells for treatment of
chronic advanced ischemic heart failure
Atta Behfar (Rochester, USA)
18.10 – 18.30 Pannel Discussion
18.30 – 18.40 Biological point of view of combination human cardiac stem cells and bone marrow mesenchymal stem cells
Joshua M. Hare (Miami, USA)
18.40 – 19.00 Pannel Discussion
19.00 – 19.10 Cardiac stem cell
Luis R. Borlado (Madrid, Spain)
19.10 – 19.30 Pannel Discussion
19.30 – 19.40 Impact of senescence in the therapeutic potential of human mesenchymal stem cells
Antonio Bernard (Madrid, Spain)
 19.40 – 20.00 Pannel Discussion

FRIDAY, 30th May 2013

FRIDAY, 30th May 2014
8.30 – 9.00 BEST POSTER PRESENTATION

Chairs: Philippe Menasche (Paris, France)
Felipe Prosper (Pamplona, Spain)

9.00 – 10.30 RECENT CONTRIBUTIONS PRESENTED BY YOUNG INVESTIGATORS

Chairs: Philippe Menasche (Paris, France)
Felipe Prosper (Pamplona, Spain)

Panel discussants: Joshua Hare (Miami, USA)
Stefanie Dimmeler (Frankfurt, Germany)
David García Dorado (Barcelona, Spain)
Bernard Gersh (Rochester, USA)

9.00 – 9.15 Stem cell-based resynchronization in myocardial infarction
Satsuki Yamada (Dr. André Terzic’s group. Rochester, USA)
9.15 – 9.30 Impact of sentence in the therapeutic potential of human mesenchymal stem cells
Juan Carlos Sepúlveda (Dr. Antonio Bernard’s group. Madrid, Spain)
9.30– 9.45 Allogeneic cell therapy; lessons learned from preclinical studies.
Sanne Jansen of Lorkeers (Dr. Steven Chamuelau’s group. Utrecht, The Netherlands)
9.45– 10.00 Generation of cardiac cells from pluripotent stem cells: limitations and challenges.
Nuria Montserrat (Dr. Angel Raya’s group. Barcelona, Spain)
10.00 – 10.15 Embryonic-stem –cell-derived cardiomyocites regenerate non-human primate hearts
James Chong (Dr. Charles Murry’s group. Seattle, USA)
10.15—10.30 Panel Discussion
10.30 – 10.45 Coffee Break
10.45 – 13.30 LATE BREAKING CLINICAL TRIALS

Chairs: Douglas W. Losordo (Chicago, USA)
Emerson Perin (Houston, USA)

Panel discussants: David García-Dorado (Barcelona, Spain)
Didier Locca (Lugano, Switzerland)
Stefan Janssens (Aalst, Belgium)
Alberto San Román (Valladolid, Spain)

10.40 – 10.55 Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and
non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: The REGENT Trial. Five years follow-up
Wociej Wojakowski (Katowice, Poland)
10.55– 11.10 Impact of intracoronary bone marrow cell therapy on left ventricular function in the
Setting of ST-segment elevation myocardial infarction: a collaborative metaanalysis
Ronak Delewi (Amsterdam, The Netherlands)
11.10 – 11.25 Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: The TAC-HFT randomized trial.
Joshua Hare (Miami, USA)
11.25– 11.40 Effect of shock wave-facilitated intracoronary cell therapy on LVEF in patients with chronic heart failure: the CELLWAVE randomized clinical trial
Andreas Zeiher (Frankfurt, Germany)
11.40– 11.55 Effect of shock wave-facilitated intracoronary cell therapy on LVEF in patients with chronic heart failure: the CELLWAVE randomized clinical trial
Birgit Assmus (Frankfurt, Germany)
11.55 – 12.10 Comparison of transendocardial and intracoronary CD34+ cell transplantation in patients with nonischemic dilated cardiomyopathy.
Bojan Wrtovec (Ljubljana, Slovenia)
12.10– 12.25 Long term survival in patients with refractory angina
Thymothy D. Henry (Los Angeles, USA)
12.30 – 12.50 Panel Discussuion
12.50– 13.15 Break
13.15 – 14.15 LOOKING TO THE FUTURE: SPECIAL SESSION
Chairs: Rafael Matesanz (Madrid, Spain)
Arturo Fernandez-Cruz (Madrid, Spain)
13.15– 13.35 Improving myocardial regeneration through stem cell rejuvenation. Is it possible?
James T. Willerson (Houston, USA)
13.35—13.55 Telomeric research and its role protecting and regenerating myocardium.
Maria Blasco (Madrid, Spain)
13.55—14.15 The revolution of human organ manufacturing. Will we use pigs as factories of human organs?
Juan Carlos Izpisua (La Jolla, USA)
14.15 – 14.55 CLOSING SESSION
FIRST MADRID CARDIAC REGENERATION AWARDS.

Chairs: John Martin (London, UK)
Rafael Matesanz (Madrid, Spain)

14.55– 15.00 ADJOURN
Francisco Fdez-Aviles (Madrid, Spain)
Konstantinos Malliaras
(Eduardo Marban’s group. Los Angeles, USA)